Alpha Glycerylphosphorylcholine, better known as Alpha GPC, is a form of choline that is used for enhancing cognitive performance and increasing power output via its influence on growth hormone production.

Alpha GPC is both a source of phospholipids and choline and is utilised for phosphatidylcholine (PC) biosynthesis in the brain and the production of acetylcholine, the chemical that allows for brain cells to communicate with each other.

Alpha GPC quickly crosses the blood-brain barrier, where it protects neurons and improves brain function and learning processes. Specifically, by the mechanism of action, Alpha GPC directly increases the synthesis and secretion of acetylcholine better than any other choline-related compound, influencing both system-wide and brain concentrations of choline.

Alpha GPC is effective for enhancing mental performance and improving memory and learning ability by counteracting the age-related loss of nerve cells and fibers in the brain.

In addition, some preliminary evidence suggests that Alpha GPC has the ability to enhance acute growth hormone production and power output during exercise. An increase in growth hormone production and power output has the ability to increase muscle mass and improve overall metabolic activity resulting in improved body composition.

How to consume

To take advantage of the cognitive enhancement and power output properties of Alpha GPC, it is best taken 15-20 minutes before exercise.

The most beneficial dose of Alpha GPC is between 500mg-1200mg per day, typically broken into 2-3 separate doses throughout the day. Studies also report that larger single doses of 600mg-800mg may be more beneficial when Alpha GPC is to be taken before exercise such as in pre-workout supplements.

Alpha GPC can quickly increase the synthesis of acetylcholine and neurotransmission in the brain, which is typically 20-30 minutes after oral consumption. Users can expect to experience an increase in mental alertness, concentration, and mental focus within this timeframe. Consistent use, in conjunction with a sensible diet and workout regime, will lead users to experience the full performance and cognitive-enhancing effects of Alpha GPC within the first 2 weeks of use.