L-Histidine is an amino acid; amino acids are used to make proteins and enzymes in the body. It is sometimes referred to as a 'semi-essential amino acid' because it is non-essential in adults, but essential in the diet of infants and those with a kidney disorder called uremia.

Histidine is used by the body to make specific hormones and metabolites that impact kidney function, the transmission of nerves, stomach secretions, and the immune system. Histidine also has an impact on the repair and growth of tissue, making blood cells and helping to protect nerve cells.

A primary function of histidine in the body is to regulate and help metabolise (break down and use for energy) trace elements.
  • Copper
  • Iron
  • Zinc
  • Manganese
  • Molybdenum, and more

Histidine also helps to form many different enzymes and compounds in the body. In addition, histidine works to formulate a compound called metallothionein inside of the cells of the brain, liver, and kidneys; metallothionein protects the brain cells and requires histidine to be formed. If a person’s body is toxic with heavy metals (such as mercury and lead), it may result in a depletion of adequate stores of histidine.